Polynucleotides - EQLibrium

Polynucleotide Treatments: The Future of Skin Regeneration

Meet the next generation of skin rejuvenation. Polynucleotide injectables—often nicknamed “salmon sperm facials” are the latest buzz in aesthetics, and for good reason. Derived from ultra-purified DNA (usually from salmon), these powerful treatments do more than hydrate like traditional skin boosters, they actively repair, regenerate, and rebalance the skin from within. By stimulating collagen, promoting tissue repair, and calming inflammation, polynucleotides leave your skin firmer, smoother, and more radiant, all without adding volume. Think of it as deep skin restoration, not just a surface glow.

At our clinic, we offer a carefully curated range of polynucleotide treatments designed to target specific concerns—from under-eye rejuvenation and pigmentation to scarring, rosacea, and overall skin quality. Scroll down to discover which options are right for you.

What is Plenhyage ?
What is Vitaran ?

All About Plenhyage

What is Plenhyage ?

Plenhyage XL is an injectable skin treatment which is designed to help tissue repair. It improves skin quality, thickness, hydration, and promotes new collagen formation, helps reduce wrinkles, fine lines, age spots, sagging, and other signs of aging while promoting healthier looking skin.

How Does Plenhyage Work ?

This polymerised, polynucleotide-based injectable gel works by stimulating fibroblasts, encouraging cell turnover, improving elasticity, boosting collagen production and hydrating the skin.

With Plenhyage XL, the active ingredient is purified PDRN. This works to boost fibroblast production, induces tissue repair processes, reduces inflammatory process, promotes hydration, promote.

It won’t give you the ‘instant volume’ that dermal fillers create, but it WILL give you a big result through regeneration of the actual tissues.

What does Plenhyage Treat ?

It is a highly versatile product which has a host of potential applications, including treatment for acne scarring, hyperpigmentation, and rosacea as well as the signs of ageing.

In addition to treatments for the upper, mid and lower face, Plenhyage XL can also be used to treat the neck, décolletage, inner arms, thighs, and knees. It will also be particularly useful for difficult areas such as the neck and beneath the eyes.

Research and clinical evidence

Research studies have shown the following effects:

115% increase in skin hydration
Over 50% increase in skin thickness
47% increase in collagen production
38% increase in skin elasticity
Reduction in inflammatory redness and improvement in rosacea and acne
Improvement in acne scarring
Reduction in pigmentation resulting from sun exposure

How long does the treatment take?

The treatment itself takes around 30 minutes. However, we may allow longer for full consultation, especially if it’s your first visit to our clinic.

How long does it last?

For best results, we’d recommend repeating treatment every 6-9 months. Regular treatments are recommended to keep your skin in fabulous condition.

Does it hurt?

Treatment is generally pain-free, but we can use a numbing cream if required.

When will i see results?

Your skin quality will improve gradually as the tissues regenerate. You’ll definitely notice the difference after 2-4 weeks, but things will continue to improve as this is a regenerative treatment. Full results can be expected about 3 months after treatment.

What is Vitaran?:

VITARAN II is our latest advanced polynucleotide injectable for bio-revitalizing skin treatment. VITARAN II offers exceptional anti-inflammatory benefits while stimulating collagen and elastin synthesis, promoting skin rejuvenation. By activating fibroblasts and other growth factors.VITARAN II aids in cellular stimulation and regeneration to repair the skin’s natural barrier. Experience the next level of skin revitalization with VITARAN II, enhancing your skincare.

VITARAN II is designed to treat various skin concerns such as fine lines, wrinkles, and skin laxity. It can also help improve skin texture and tone, reduce inflammation, and enhance overall skin rejuvenation. This injectable works by stimulating collagen and elastin production, which are essential proteins for maintaining youthful and healthy skin. Additionally, VITARAN II supports cellular regeneration to repair the skin’s natural barrier, making it beneficial for individuals seeking skin revitalization and anti-aging treatments.

What can i expect in my Treatment Process:

The Vitaran II procedure is quick, minimally invasive. Your practitioner will skillfully administer a series of tiny injections into targeted areas using a fine needle. The entire process can be completed within 45 as we like to have a consultation and leave time to numb, depending on the number of treatment areas.

– Results and Recovery:
Following the Vitaran II treatment, you can expect to see initial results within a few days, with the full effects becoming evident after approximately two weeks. Vitaran II is known for its minimal downtime, allowing you to resume your regular activities after the procedure. However, your practitioner may advise you to avoid strenuous exercise and excessive sun exposure for a short period.

Can I drink alcohol before my treatment?

Drinking alcohol is not recommended before a treatment as it can thin the blood leading to a higher risk of bruising and swelling.

How can I prepare for my treatment ?

Taking arnica supplements before your treatment can help minimise risk of bruising
Staying hydrated can help minimise risk of bruising and swelling.
Let your practitioner know prior to the treatment if you are on any blood thinning medications.

Can I drink alcohol before my treatment?

Drinking alcohol is not recommended before a treatment as it can thin the blood leading to a higher risk of bruising and swelling.

Maintain a normal heart rate.
Avoid touching, rubbing, or applying physical pressure to the treated area.
Allow the treated area to settle undisturbed.
Wait 12 hours before engaging in exercise.

If exercise is part of your daily routine, wait at least 24 hours before working out. Physical activity increases the risk of bruising and sweating, which can also elevate the chances of infection.

Go makeup-free.

If you received injections on your face, refrain from applying makeup for 12 hours. Makeup application can cause friction on the skin and heightens chances of infection.

Avoid other skin treatments for 2 weeks.

The injection sites require time to heal. It’s advisable to wait a week before undergoing other treatments that may irritate or disturb the injection site, such as facial massages, exfoliating scrubs, or dermal fillers. Getting these treatments too soon may lead to irritation or infection.

EQ Transformations

Aesthetics is such an art but also a science. Profile balancing and harmonisation is so important. Every feature must compliment another. I have perfected my own signature techniques that deliver the most amazing results. I believe I can make most people look at least 10 years younger as well as refreshed, balanced and beautified.

Natasha Gordana Murray International & UK Leading PDO thread & aesthetic expert Weybridge, Surrey & Harley Street, London Book a Free Consultation

PROFHILO

Profhilo skin boosters are a very popular treatment for patients who want to reduce the effects of ageing and restore youthful radiance. We may also recommend Profhilo as a complementary treatment for enhanced results.

Sunekos

Sunekos skin boosters stimulate the natural production of collagen and elastin in the skin. The result is deeply hydrated, plumped skin. Sunekos uses a patented formula, which combines amino acids with hyaluronic acid. The unique ingredients in Sunekos work together with the skin’s Extra Cellular Matrix to promote the production of collagen and elastin, which has a plumping and lifting effect.

Jalupro

alupro skin boosters have a unique ‘bio revitalising’ action. Jalupro may be recommended for patients who would like to address skin texture issues, such as acne scarring. Jalupro stimulates the skin’s natural ability to regenerate, resulting in deeply hydrated, smoothed skin. The combined ingredients of amino acids and hyaluronic acid in Jalupro stimulate the production of collagen. This promotes elasticity, firmness and tone, to reduce the signs of ageing, scarring and sun damage.

Nucleofill Polynucleotides

Polynucleotides are chains of molecules called nucleotides that form the structure of DNA. Nucleofill polynucleotide skin boosters act on dermal cells to stimulate the production of collagen fibres and encourage cell renewal and repair. Polynucleotides are highly effective for reducing acne scarring and repairing damaged tissue. Their deeply hydrating effect improves overall skin texture.

Restylane

The formulation of hyaluronic acid in Restylane Skinboosters refreshes the skin by hydrating it, restoring a smooth, soft texture. Restylane Skinboosters boost the elasticity of the skin to provide a healthier, radiant appearance. They are particularly effective at reducing the effects of sun damage and reducing smoker’s lines.

AT A GLANCE

N/A

Anaesthetic required

30 MINUTES

Appointment time

MINIMAL

Pain/Discomfort

10-15 MINS

Downtime

3-4 MONTHS

Frequency of treatment

CONDITIONS TREATS

Loss of elasticity

General skin health

Lines & wrinkles

Menopausal skin

Sun damaged skin

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"From the first phone call to reception through to time spent with the doctors, I had absolute confidence that the clinic's team was focused solely on what was the optimal treatment for me."

JE, Lawyer

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"Amazing experience! The team was incredibly knowledgeable, and the results exceeded my expectations. I can't wait for my next appointment."

Sarah Johnson

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"Excellent service and highly professional staff. I felt very comfortable and well-informed throughout the process. Highly recommended!"

Mark T.

Skin Boosters Treatment Guide & FAQs

WAt Equilibrium Clinic Weybridge, Surrey & Harley St, London, we specialise in elegant and natural looking full facial transformations. We use the art of beautification and profile balancing to balance and optimise an individual’s facial profile by altering the proportions of the face through the use of a combination of methods depending on our clients’ needs and suitability. Rather than altering specific facial features, this treatment takes an overall view of your profile, considering the proportions of the nose, forehead, cheeks, lips, chin and jawline. We optimise the lateral profile based on convexities, projection, angles, ratios and proportion based on geometric facial aesthetic ideals.
We work on:

Structure

Volume

Ratios

Skin tightening

Skin health